Intracellular Synthesis of Hybrid Gallium-68 Nanoparticle Enhances MicroPET Tumor Imaging

Positron-emission tomography (PET) imaging enables cancer diagnosis at an early stage and to determine its pathological degree. However, tumor uptake efficiency of traditional PET radiotracers is usually low. Herein, we rationally designed a precursor CBT-NODA, the cold analogue CBT-NODA-Ga, corresponding radiotracer CBT-NODA-68Ga. Using these three compounds, verified that coinjection CBT-NODA-68Ga with CBT-NODA or CBT-NODA-Ga could lead synthesis hybrid gallium-68 nanoparticles in furin-overexpressing cells enhance microPET mice. In vivo experiments showed had most prolonged retention blood, highest radioactivity regions, enhanced We anticipate that, by combining strategy our CBT-Cys click condensation reaction, more are developed for tumors clinical settings future.